Education and Training
Dr. Ivana Mižik obtained her Ph.D under the supervision of Prof. Dr. Werner Seeger and Prof. Dr. Rory E. Morty at the Justus-Liebig-University in Giessen and the Max Planck Institute for Heart and Lung Research in Bad Neuhei, Germany. She continued her postdoctoral training under the supervision of Prof. Dr. Bernard Thébaud at the Sinclair Centre for Regenerative Medicine at Ottawa Hospital Research Institute in Ottawa, Canada and later Prof. Dr. Miguel Alejandre-Alcázar at the University Hospital Cologne, Germany. Since 2024 she leads a TLRC Junior Research Group “Lung-Microbiota Interactions in Development, Health and Disease”.
Expertise
Dr. Mižik has an extensive background in postnatal lung development and the pathogenesis of Bronchopulmonary dysplasia (BPD), which has been a primary focus of her research for the past decade. In recent years, her interests further expanded into fetal lung development, regeneration and lung resident mesenchymal stem cells.
The current research in the Mižik laboratory focuses on understanding the early post-natal pulmonary cellular landscape in BPD, with emphasis on epithelial and activated immune cell populations, as well as lung microbiome.
- Hyperoxia-induced immune populations in BPD
- Pulmonary epithelial landscape in BPD lungs
- Microbiome-lung interactions in postnatal lung development and BPD
- DPLD
Renesme L, Lesage F, Cook DP, Achutan A., Zhong S, Hänninen SM, Carpén O, Mižik I*, Thébaud B*.A human single-nuclei atlas reveals novel cell states during the pseudoglandular-to-canalicular transition. Am J Respir Cell Mol BIol, 2025. Doi: 10.1165/rcmb.2024-0244OC
C. Cyr-Depauw, I. Mižik, D.P. Cook, F. Lesage, A Vadivel, L. Renesme, Y. Deng, S. Zhong, Pauline Bardin, L. Xu, M. A. Möbius, J. Marzahn, D. Freund, D. J. Stewart, B. C. Vanderhyden, M. Rüdiger, B. Thébaud. Single-Cell RNA Sequencing to Guide Autologous Preterm Cord Mesenchymal Stromal Cell-Therapy. Am J Respir Crit Care Med, 2025; 211(3):391-406. doi: 10.1164/rccm.202403-0569OC.PMID: 39586004
C. Cyr-Depauw, D.P. Cook, I. Mižik, F. Lesage, A Vadivel, L. Renesme, Y. Deng, S. Zhong, Pauline Bardin, L. Xu, M. A. Möbius, J. Marzahn, D. Freund, D. J. Stewart, B. C. Vanderhyden, M. Rüdiger, B. Thébaud. Single-Cell RNA Sequencing Reveals Repair Features of Human Umbilical Cord Mesenchymal Stromal Cells. Am J Respir Crit Care Med, 2024; 210(6):814-827. doi: 10.1164/rccm.202310-1975OC.PMID: 38564376
Mižíková I, Lesage F, Cyr-Depauw C, Cook DP, Hurskainen M, Hänninen SM, Vadivel A, Bardin P, Zhong S, Carpén O, Vanderhyden B, Thébaud B. Single-cell RNA sequencing-based characterization of resident lung mesenchymal stromal cells in bronchopulmonary dysplasia. Stem Cells
, 2022; 40(5):479-492. doi.org/10.1093/stmcls/sxab023
Mižíková I, Thébaud B. Looking at the developing lung in single-cell resolution. Am J Physiol Lung Cell Mol Physiol
, 2021; 320: L680–L687. doi.org/10.1152/ajplung.00385.2020
Mižíková I.*, Hurskainen M.*, Cook D.P, Andersson N., Cyr-Depauw C., Lesage F., Helle E., Renesme L., Jankov R.P., Heikinheimo M., Vanderhyden B.C., Thébaud B. Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage. Nat Commun,
2021; 12(1):1565. doi.org/10.1038/s41467-021-21865-2
Mižíková I, Pfeffer T, Nardiello C, Surate Solaligue DE, Steenbock H, Tatsukawa H, Silva DM, Vadász I, Herold S, Pease RJ, Iismaa SE, Hitomi K, Seeger W, Brinckman J, Morty RE. Targeting transglutaminase 2 during aberrant alveolarization partially restores extracellular matrix structure but not alveolar architecture in developing lungs. FEBS J
; 2018. 285(16):3056-3076. doi.org/10.1111/febs.14596
Hönig J, Mižíková I,Nardiello C, Surate Solaligue DE, Daume MJ, Vadász I, Mayer K, Herold S, Günter S, Seeger W, Morty RE. Transmission of microRNA antimiRs to Mouse Offspring via the Maternal-Placental-Fetal Unit. RNA
, 2018. 24(6):865-879. doi.org 10.1261/rna.063206.117
Mižíková I, Palumbo F, Tábi T, Herold S, Vadász I, Mayer K, Seeger W, Morty RE. Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts. Physiological Genomics
. 2017. 49(8): p. 416-429. doi.org/10.1152/physiolgenomics.00026.2017
Nardiello C, Mižíková I, Silva DM, Ruiz-Camp J, Mayer K, Vadász I, Herold S, Seeger W, Morty RE. Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia. Dis Model Mech
; 2017. 10(2): p. 185-196. doi.org/10.1242/dmm.027086
Mižíková, I and RE Morty. The Extracellular Matrix in Bronchopulmonary Dysplasia: Target and Source. Front Med
(Lausanne), 2015. 2: p. 91. doi.org/10.3389/fmed.2015.00091
Mižíková I, Ruiz-Camp J, Madurga A, Vadász I, Herold S, Mayer K, Seeger W, Morty RE. Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia. Am J Physiol Lung Cell Mol Physiol
, 2015. 308(11): p. L1145- 1158. doi.org/10.1152/ajplung.00039.2015
Nave, AH, Mižíková, I, Niess G, Steenbock H, Reichenberger F, Talavera ML, Veit F, Herold S, Mayer K, Vadász I, Weissmann N, Seeger W, Brinckmann J, Morty RE. Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol
, 2014. 34(7): p. 1446-58. doi.org 10.1161/ATVBAHA.114.303534
Ariani Syafitri Rahadian | PhD Student |
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Sara D’Agostino | PhD Student |
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Ümran Turan | PhD Student |
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Lung Research - Projects
1. Hyperoxia-induced immune populations in BPD.
The project investigates the behavior of selected macrophage subpopulations and their interactions with other cell populations during normal post-natal lung development, as well as their specific roles in the pathogenesis of BPD.
2. Pulmonary epithelial landscape in BPD lungs.
The project aims to understand the role of diverse epithelial subpopulations in normal post-natal lung development and BPD.
3. Microbiome-lung interactions in postnatal lung development and BPD.
The project aims to map the interactions between diverse lung cell populations and the pulmonary microbiome, as well as their potential implications in the BPD pathogenesis.