New this week - TLRC Faculty 2022
Woche 52 (26.12 - 31.12)
Communication with patients with limited prognosis-an integrative mixed-methods evaluation study. Siegle A, Unsöld L, Deis N, Krug K, Bossert J, Krisam J, Jung C, Jünger J, Wensing M, Thomas M, Villalobos M. Support Care Cancer. 2022 Dec 22;31(1):77. doi: 10.1007/s00520-022-07474-9. PMID: 36547732
[Guideline-based digital smoking cessation with computer, tablet or smartphone]. Rupp A, Hering T, Bubeck A, Kreuter M. Dtsch Med Wochenschr. 2022 Dec 23. doi: 10.1055/a-1984-7424. Online ahead of print. PMID: 36564019 German.
Clusters of comorbidities in fibrotic hypersensitivity pneumonitis. Prior TS, Wälscher J, Gross B, Bendstrup E, Kreuter M. Respir Res. 2022 Dec 21;23(1):368. doi: 10.1186/s12931-022-02291-4. PMID: 36539821
Cardiovascular predictors of mortality and exacerbations in patients with COPD. Alter P, Lucke T, Watz H, Andreas S, Kahnert K, Trudzinski FC, Speicher T, Söhler S, Bals R, Waschki B, Welte T, Rabe KF, Vestbo J, Wouters EFM, Vogelmeier CF, Jörres RA. Sci Rep. 2022 Dec 19;12(1):21882. doi: 10.1038/s41598-022-25938-0. PMID: 36536050
Lung cancer in patients with idiopathic pulmonary fibrosis: A retrospective multicentre study in Europe. Karampitsakos T, Spagnolo P, Mogulkoc N, Wuyts WA, Tomassetti S, Bendstrup E, Molina-Molina M, Manali ED, Unat ÖS, Bonella F, Kahn N, Kolilekas L, Rosi E, Gori L, Ravaglia C, Poletti V, Daniil Z, Prior TS, Papanikolaou IC, Aso S, Tryfon S, Papakosta D, Tzilas V, Balestro E, Papiris S, Antoniou K, Bouros D, Wells A, Kreuter M, Tzouvelekis A. Respirology. 2023 Jan;28(1):56-65. doi: 10.1111/resp.14363. Epub 2022 Sep 18. PMID: 36117239
Effectiveness of Nivolumab in Second-Line and Later in Patients with Advanced Non-Small Cell Lung Cancer in Real-Life Practice in France and Germany: Analysis of the ESME-AMLC and CRISP Cohorts. Chouaid C, Thomas M, Debieuvre D, Durand-Zaleski I, Zacharias S, Bosquet L, Groth A, Fleitz A, Calleja A, Patel S, Lacoin L, Daumont MJ, Penrod JR, Carroll R, Waldenberger D, Cotté FE, Audigier-Valette C, Griesinger F. Cancers (Basel). 2022 Dec 13;14(24):6148. doi: 10.3390/cancers14246148. PMID: 36551632
Longitudinal MRI Detects Onset and Progression of Chronic Rhinosinusitis from Infancy to School Age in Cystic Fibrosis. Wucherpfennig L, Wuennemann F, Eichinger M, Schmitt N, Seitz A, Baumann I, Stahl M, Graeber SY, Chung J, Schenk JP, Alrajab A, Kauczor HU, Mall MA, Sommerburg O, Wielpütz MO. Ann Am Thorac Soc. 2022 Dec 22. doi: 10.1513/AnnalsATS.202209-763OC. Online ahead of print. PMID: 36548543
Quantitative CT analysis of lung parenchyma to improve malignancy risk estimation in incidental pulmonary nodules. Peters AA, Weinheimer O, von Stackelberg O, Kroschke J, Piskorski L, Debic M, Schlamp K, Welzel L, Pohl M, Christe A, Ebner L, Kauczor HU, Heußel CP, Wielpütz MO. Eur Radiol. 2022 Dec 20. doi: 10.1007/s00330-022-09334-w. Online ahead of print. PMID: 36538071
Week 51 (19.12 - 25.12)
[What have we learned from the German COPD cohort COSYCONET and where do we go from here?]. Kahnert K, Fischer C, Alter P, Trudzinski F, Welte T, Behr J, Herth F, Kauczor HU, Bals R, Watz H, Rabe K, Söhler S, Kokot I, Vogelmeier C, Jörres R. Pneumologie. 2022 Dec 16. doi: 10.1055/a-1966-0848. Online ahead of print. PMID: 36526266 German.
Effectiveness of Extrafine Single Inhaler Triple Therapy in Chronic Obstructive Pulmonary Disease (COPD) in Germany - The TriOptimize Study. Gessner C, Trinkmann F, Bahari Javan S, Hövelmann R, Bogoevska V, Georges G, Nudo E, Criée CP. Int J Chron Obstruct Pulmon Dis. 2022 Dec 2;17:3019-3031. doi: 10.2147/COPD.S382405. eCollection 2022. PMID: 36483674
Multimodal therapy of epithelioid pleural mesothelioma: improved survival by changing the surgical treatment approach. Klotz LV, Hoffmann H, Shah R, Eichhorn F, Gruenewald C, Bulut EL, Griffo R, Muley T, Christopoulos P, Baum P, Huber P, Safi S, Kriegsmann M, Thomas M, Bischoff H, Winter H, Eichhorn ME. Transl Lung Cancer Res. 2022 Nov;11(11):2230-2242. doi: 10.21037/tlcr-22-199. PMID: 36519024
Week 50 (12.12 - 18.12)
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients. Janke F, Angeles AK, Riediger AL, Bauer S, Reck M, Stenzinger A, Schneider MA, Muley T, Thomas M, Christopoulos P, Sültmann H. Clin Epigenetics. 2022 Dec 2;14(1):163. doi: 10.1186/s13148-022-01387-4. PMID: 36461127
Dynamic contrast enhanced MRI of pulmonary adenocarcinomas for early risk stratification: higher contrast uptake associated with response and better prognosis. Rheinheimer S, Christopoulos P, Erdmann S, Saupe J, Golpon H, Vogel-Claussen J, Dinkel J, Thomas M, Heussel CP, Kauczor HU, Heussel G. BMC Med Imaging. 2022 Dec 5;22(1):215. doi: 10.1186/s12880-022-00943-x. PMID: 36471318
Magnetic resonance imaging detects improvements of pulmonary and paranasal sinus abnormalities in response to elexacaftor/tezacaftor/ivacaftor therapy in adults with cystic fibrosis. Wucherpfennig L, Triphan SMF, Wege S, Kauczor HU, Heussel CP, Schmitt N, Wuennemann F, Mayer VL, Sommerburg O, Mall MA, Eichinger M, Wielpütz MO. J Cyst Fibros. 2022 Nov;21(6):1053-1060. doi: 10.1016/j.jcf.2022.03.011. Epub 2022 Apr 8. PMID: 35400600
Profiles and treatment patterns of patients with pulmonary arterial hypertension on monotherapy at experienced centres. Wissmüller M, Xanthouli P, Benjamin N, Grünig E, Richter MJ, Gall H, Ghofrani HA, Herkenrath S, Skowasch D, Pizarro C, Halank M, Hohmann C, Hellmich M, Gerhardt F, Rosenkranz S. ESC Heart Fail. 2022 Oct;9(5):2873-2885. doi: 10.1002/ehf2.13804. Epub 2022 Jun 15. PMID: 35706353
Implementation of a spontaneous awakening/spontaneous breathing trial protocol in a surgical intensive care unit: a before and after study. Desantis M, Lichtenstern C, Hagenlocher JP, Bruckner T, Weigand MA, Kalenka A, Fiedler MO. Minerva Anestesiol. 2022 Dec 7. doi: 10.23736/S0375-9393.22.16806-9. Online ahead of print. PMID: 36475396
Effectiveness of Extrafine Single Inhaler Triple Therapy in Chronic Obstructive Pulmonary Disease (COPD) in Germany - The TriOptimize Study. Gessner C, Trinkmann F, Bahari Javan S, Hövelmann R, Bogoevska V, Georges G, Nudo E, Criée CP. Int J Chron Obstruct Pulmon Dis. 2022 Dec 2;17:3019-3031. doi: 10.2147/COPD.S382405. eCollection 2022. PMID: 36483674
Week 7 (14.02.-20.02.)
Microwave ablation via a flexible catheter for the treatment of nonsurgical peripheral lung cancer: A pilot study. Xie F, Chen J, Jiang Y, Sun J, Hogarth DK, Herth FJF. Thorac Cancer. 2022 Feb 14. doi: 10.1111/1759-7714.14351. Online ahead of print. PMID: 35166043
Week 6 (07.02.-13.02.)
Fatum inexorabile - Do Monocytes Predict the Fate of Interstitial Lung Abnormalities?! Kreuter M, Maher TM. Am J Respir Crit Care Med. 2022 Feb 11. doi: 10.1164/rccm.202201-0049ED. Online ahead of print. PMID: 35148483 No abstract available.
Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk. Li Y, Xiao X, Li J, Byun J, Cheng C, Bossé Y, McKay J, Albanes D, Lam S, Tardon A, Chen C, Bojesen SE, Landi MT, Johansson M, Risch A, Bickeböller H, Wichmann HE, Christiani DC, Rennert G, Arnold S, Goodman G, Field JK, Davies MPA, Shete SS, Le Marchand L, Melander O, Brunnström H, Liu G, Hung RJ, Andrew AS, Kiemeney LA, Shen H, Sun R, Zienolddiny S, Grankvist K, Johansson M, Caporaso N, Teare DM, Hong YC, Lazarus P, Schabath MB, Aldrich MC, Schwartz AG, Gorlov I, Purrington K, Yang P, Liu Y, Han Y, Bailey-Wilson JE, Pinney SM, Mandal D, Willey JC, Gaba C, Brennan P, Amos CI; INTEGRAL-ILCCO lung cancer consortium. Hum Mol Genet. 2022 Feb 9:ddac030. doi: 10.1093/hmg/ddac030. Online ahead of print. PMID: 35138370
Dyspnoea and cough in patients with systemic sclerosis-associated interstitial lung disease in the SENSCIS trial. Volkmann ER, Kreuter M, Hoffmann-Vold AM, Wijsenbeek M, Smith V, Khanna D, Denton CP, Wuyts WA, Miede C, Alves M, Sambevski S, Allanore Y; SENSCIS trial investigators. Rheumatology (Oxford). 2022 Feb 12:keac091. doi: 10.1093/rheumatology/keac091. Online ahead of print. PMID: 35150246
Week 5 (31.01.-06.02.)
Incidental findings on lung cancer screening: pictorial essay and systematic checklist. Penha D, Pinto E, Monaghan C, Hochhegger B, Marchiori E, Taborda-Barata L, Irion K, Ravara S, Kauczor HU. J Bras Pneumol. 2022 Feb 2;48(1):e20210371. doi: 10.36416/1806-3756/e20210371. eCollection 2022. PMID: 35137873 English, Portuguese.
Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer. Rosenberger A, Muttray N, Hung RJ, Christiani DC, Caporaso NE, Liu G, Bojesen SE, Le Marchand L, Albanes D, Aldrich MC, Tardon A, Fernández-Tardón G, Rennert G, Field JK, Davies MPA, Liloglou T, Kiemeney LA, Lazarus P, Wendel B, Haugen A, Zienolddiny S, Lam S, Schabath MB, Andrew AS, Duell EJ, Arnold SM, Goodman GE, Chen C, Doherty JA, Taylor F, Cox A, Woll PJ, Risch A, Muley TR, Johansson M, Brennan P, Landi MT, Shete SS, Amos CI, Bickeböller H; INTEGRAL-ILCCO Consortium. Eur J Med Res. 2022 Jan 31;27(1):14. doi: 10.1186/s40001-022-00638-7. PMID: 35101137 Free PMC article.
Acute Phase Proteins as Early Predictors for Immunotherapy Response in Advanced NSCLC: An Explorative Study. Schneider MA, Rozy A, Wrenger S, Christopoulos P, Muley T, Thomas M, Meister M, Welte T, Chorostowska-Wynimko J, Janciauskiene S. Front Oncol. 2022 Jan 31;12:772076. doi: 10.3389/fonc.2022.772076. eCollection 2022. PMID: 35174082 Free PMC article.
Commensal Bacteria in the Cystic Fibrosis Airway Microbiome Reduce P. aeruginosa Induced Inflammation. Tony-Odigie A, Wilke L, Boutin S, Dalpke AH, Yi B. Front Cell Infect Microbiol. 2022 Jan 31;12:824101. doi: 10.3389/fcimb.2022.824101. eCollection 2022. PMID: 35174108 Free PMC article.
Week 4 (24.01.-30.01.)
Reduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment. Kahnert K, Andreas S, Kellerer C, Lutter JI, Lucke T, Yildirim Ö, Lehmann M, Seissler J, Behr J, Frankenberger M, Bals R, Watz H, Welte T, Trudzinski FC, Vogelmeier CF, Alter P, Jörres RA; COSYCONET Study Group. Sci Rep. 2022 Jan 26;12(1):1435. doi: 10.1038/s41598-022-05276-x. PMID: 35082306 Free PMC article.
Utility of Automated Cardiac Chamber Volumetry by Non-Gated CT Pulmonary Angiography for Detection of Pulmonary Hypertension Using the 2018 Updated Hemodynamic Definition. Melzig C, Do TD, Egenlauf B, Fink MA, Grünig E, Kauczor HU, Heussel CP, Rengier F. AJR Am J Roentgenol. 2022 Jan 26. doi: 10.2214/AJR.21.27147. Online ahead of print. PMID: 35080457
Iam hiQ-a novel pair of accuracy indices for imputed genotypes. Rosenberger A, Tozzi V, Bickeböller H; INTEGRAL-ILCCO consortium. BMC Bioinformatics. 2022 Jan 24;23(1):50. doi: 10.1186/s12859-022-04568-3. PMID: 35073846 Free PMC article
µCT to quantify muco-obstructive lung disease and effects of neutrophil elastase knockout in mice. Zhu L, Duerr J, Zhou-Suckow Z, Wagner WL, Weinheimer O, Salomon JJ, Leitz D, Konietzke P, Yu H, Ackermann M, Stiller W, Kauczor HU, Mall MA, Wielpütz MO. Am J Physiol Lung Cell Mol Physiol. 2022 Jan 26. doi: 10.1152/ajplung.00341.2021. Online ahead of print. PMID: 35080183
Week 3 (17.01.-23.01.)
Histological and Molecular Plasticity of ALK-positive Non-Small-Cell Lung Cancer under Targeted Therapy - a Case Report. Ball M, Christopoulos P, Kirchner M, Allgaeuer M, Brandt R, Winter H, Heussel CP, Herth F, Froehling S, Savai R, Kriegsmann M, Schirmacher P, Peters S, Thomas M, Stenzinger A, Kazdal D. Cold Spring Harb Mol Case Stud. 2022 Jan 20:mcs.a006156. doi: 10.1101/mcs.a006156. Online ahead of print. PMID: 35058282
Phase 2b Study of Inhaled RVT-1601 for Chronic Cough in Idiopathic Pulmonary Fibrosis: SCENIC Trial: Multi-Center, Randomized, Placebo-Controlled Study. Martinez FJ, Wijsenbeek MS, Raghu G, Flaherty KR, Maher TM, Wuyts WA, Kreuter M, Kolb M, Chambers DC, Fogarty C, Mogulkoc N, Tutuncu AS, Richeldi L. Am J Respir Crit Care Med. 2022 Jan 20. doi: 10.1164/rccm.202106-1485OC. Online ahead of print. PMID: 35050837
Clinical characterization and possible pathophysiological causes of the Deventilation Syndrome in COPD. Schellenberg MD, Imach S, Iberl G, Kirchner M, Herth F, Trudzinski F. Sci Rep. 2022 Jan 20;12(1):1099. doi: 10.1038/s41598-022-05118-w. PMID: 35058534
Week 2 (10.01.-16.01.)
Risk-Adjusted Mortality Rates as a Quality Proxy Outperform Volume in Surgical Oncology-A New Perspective on Hospital Centralization Using National Population-Based Data. Baum P, Lenzi J, Diers J, Rust C, Eichhorn ME, Taber S, Germer CT, Winter H, Wiegering A. J Clin Oncol. 2022 Jan 11:JCO2101488. doi: 10.1200/JCO.21.01488. Online ahead of print. PMID: 35015575
Impact of lung function decline on time to hospitalisation events in systemic sclerosis-associated interstitial lung disease (SSc-ILD): a joint model analysis. Kreuter M, Del Galdo F, Miede C, Khanna D, Wuyts WA, Hummers LK, Alves M, Schoof N, Stock C, Allanore Y. Arthritis Res Ther. 2022 Jan 10;24(1):19. doi: 10.1186/s13075-021-02710-9. PMID: 35012623 Free PMC article
[Chest X-ray: implementation and indication : Recommendations of the thoracic imaging working group of the German Radiological Society]. Ley S, Biederer J, Ley-Zaporozhan J, Wielpütz MO, Vogel-Claussen J, Das M, Hamer O. Radiologe. 2022 Jan 10. doi: 10.1007/s00117-021-00952-x. Online ahead of print. PMID: 35006315 Review. German.
Adaptive MR-Guided Stereotactic Radiotherapy is Beneficial for Ablative Treatment of Lung Tumors in High-Risk Locations. Regnery S, Buchele C, Weykamp F, Pohl M, Hoegen P, Eichkorn T, Held T, Ristau J, Rippke C, König L, Thomas M, Winter H, Adeberg S, Debus J, Klüter S, Hörner-Rieber J. Front Oncol. 2022 Jan 11;11:757031. doi: 10.3389/fonc.2021.757031. eCollection 2021. PMID: 35087746 Free PMC article.
Week 1 (03.01.-09.01.)
[Addictive inhalants-A challenge for the lungs]. Bauer-Kemény C, Kreuter M. Pneumologe (Berl). 2022 Jan 4:1-11. doi: 10.1007/s10405-021-00428-8. Online ahead of print. PMID: 35002591 Free PMC article. German.
Endoscopic Elastography: Toy or Tool? Herth FJF, Brock J. J Bronchology Interv Pulmonol. 2022 Jan 1;29(1):5-6. doi: 10.1097/LBR.0000000000000820. PMID: 34935668 No abstract available.
Fusion-positive non-small cell lung carcinoma: Biological principles, clinical practice and diagnostic implications. Kazdal D, Hofman V, Christopoulos P, Ilié M, Stenzinger A, Hofman P. Genes Chromosomes Cancer. 2022 Jan 8. doi: 10.1002/gcc.23022. Online ahead of print. PMID: 34997651 Review.
Systems Approaches to Unravel Molecular Function: High-content siRNA Screen Identifies TMEM16A Traffic Regulators as Potential Drug Targets for Cystic Fibrosis. Pinto MC, Botelho HM, Silva IAL, Railean V, Neumann B, Pepperkok R, Schreiber R, Kunzelmann K, Amaral MD. J Mol Biol. 2022 Jan 3:167436. doi: 10.1016/j.jmb.2021.167436. Online ahead of print. PMID: 34990652
Clinical characterization of a novel alpha1-antitrypsin null variant: PiQ0Heidelberg. Presotto MA, Veith M, Trinkmann F, Schlamp K, Polke M, Eberhardt R, Herth F, Trudzinski FC. Respir Med Case Rep. 2022 Jan 3;35:101570. doi: 10.1016/j.rmcr.2021.101570. eCollection 2022. PMID: 35028284 Free PMC article.
Essential Features of an Interstitial Lung Disease Multidisciplinary Meeting: An International Delphi Survey. Teoh AKY, Holland AE, Morisset J, Flaherty KR, Wells AU, Walsh SLF, Glaspole I, Wuyts WA, Corte TJ; ILD MDM Delphi Collaborators. Ann Am Thorac Soc. 2022 Jan;19(1):66-73. doi: 10.1513/AnnalsATS.202011-1421OC. PMID: 34191689