Education and Training
Marc Schneider manages the Lung Biobank Heidelberg which is integrated in the Translational Research Unit (STF) at Thoraxklinik. After graduating in Biology at the University of Mainz, he conducted his PhD studies in Virology at University Medical Center Mainz. He finished his PhD in 2011 and joined the STF at Thoraxklinik in 2012.
Expertise
The main emphasis of the STF and the Lung Biobank Heidelberg is the interdisciplinary support and promotion of translational lung research projects. Marc Schneider supervises, coordinates and supports translational research projects. The provision of retrospective or prospective collected biomaterials and clinical data is the main task of the lung biobank. Besides, the STF offers a broad methodological spectrum (e.g. gene expression analyses, primary cell culture models) to support research projects. An ongoing in-house research project focuses on the function of glycodelin in lung cancer.
- Improvement of biobanking processes
- Identification of biomarkers in tissue and liquid samples
- Development of cell culture models
- Lung Cancer
- Diffuse Parenchymal Lung Disease
- Chronic Obstructive Pulmonary Disease / Biobanking
- Janke J, Bozorgmehr F, Wrenger S, Dietz S, Heussel CP, Heussel G, Silva CF, Rheinheimer S, Feisst M, Thomas M, Golpon H, Günther A, Sültmann H, Muley T, Janciauskiene S, Meister M, Schneider MA. Novel Liquid Biomarker Panels for A Very Early Response Capturing of NSCLC Therapies in Advanced Stages. Cancers 2020, 12, 954.
- Lukassen S*, Lorenz Chua R*, Trefzer T*, Kahn NC*, Schneider MA*, Muley T, Winter H, Meister M, Veith C, Boots AW et al. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J 2020, 10.15252/embj.20105114, doi:10.15252/embj.20105114.
- Ercetin E, Richtmann S, Delgado BM, Gomez-Mariano G, Wrenger S, Korenbaum E, Liu B, DeLuca D, Kühnel MP, Jonigk D, Yuskaeva K, Warth A, Muley T, Winter H, Meister M, Welte T, Janciauskiene S*, Schneider MA*. Clinical Significance of SERPINA1 Gene and Its Encoded Alpha1-antitrypsin Protein in NSCLC. Cancers (Basel). 2019 Sep 4;11(9). pii: E1306. doi: 10.3390/cancers11091306.
- Schneider MA, Muley T, Kahn NC, Warth A, Thomas M, Herth JF, et al. Glycodelin is a potential novel follow-up biomarker for malignant pleural mesothelioma. Oncotarget, 2016 Oct 4. doi: 10.18632/oncotarget.12474.
- Schneider MA, Granzow M, Warth A, Schnabel PA, Thomas M, Herth FJF, Dienemann H, Muley T, Meister, M. Glycodelin: A new Biomarker with Immunomodulatory Functions in Non-Small Cell Lung Cancer. Clin Cancer Res 2015 Aug 1;21(15):3529-40. doi: 10.1158/1078-0432.CCR-14-2464
Lung Research - Projects
- Improvement of biobanking processes
For translational research projects, the quality of biomaterial is essential. The team regularly evaluates processes to improve the sample quality and to optimize processes. They introduced an IT-based sample management system to add and provide essential sample parameters to our collected biomaterial. To improve the storage and documentation of their samples and data, a permanent exchange with their biobank partners takes place. Here, they have also taken part in biorepository proficiency testing programs and trainings for their biobank employees. - Identification of biomarkers in tissue and liquid samples
Using biomaterial and clinical data from Lung Biobank Heidelberg, together with their DZL cooperation partners, they have been working on identification of diagnostic, prognostic and therapeutic biomarkers in benign and malignant lung diseases for years. - Development of cell culture models (air-liquid-interface cultures, primary cell culture, organoid cultures)
With biomaterial from the Lung Biobank Heidelberg they permanently work on the development of new cell culture models. They use these models for in-house research but also provide these models to their DZL partners. Among other things, this includes primary cultures from benign or malignant tissues, air liquid interface cultures or organoid cultures. - The role of immune system in patients with lung cancer
Currently, the immune system and its role in lung cancer development and spread is one focus of DZL research. The team of the Translational Research Unit, has focused on glycodelin, a pregnancy-associated protein. They are interested in the regulation and function of glycodelin in non-small cell lung cancer (NSCLC) and whether this protein might be a target for intervention.
