Diese Woche Neu TLRC Fakultät 2025
Woche 11 (10.03. - 16.03.)
Low-coverage whole genome sequencing of cell-free DNA to predict and track immunotherapy response in advanced non-small cell lung cancer. Janke F, Gasser M, Angeles AK, Riediger AL, Görtz M, Appenheimer L, Laut AK, Ogrodnik S, Gerhardt S, Stenzinger A, Schneider MA, Thomas M, Christopoulos P, Sültmann H. J Exp Clin Cancer Res. 2025 Mar 8;44(1):87. doi: 10.1186/s13046-025-03348-0. PMID: 40055810; PMCID: PMC11889826.
Effects of cigarette-derived compounds on the spread of antimicrobial resistance in artificial human lung sputum medium, simulated environmental media and wastewater. Fang P, Konyali D, Fischer E, Mayer RP, Huang J, Elena AX, Orzechowski GH, Tony-Odigie A, Kneis D, Dalpke A, Krebs P, Li B, Berendonk TU, Klümper U. Environ Health Perspect. 2025 Mar 3. doi: 10.1289/EHP14704. Epub ahead of print. PMID: 40032488.
Sex-Specific Differences in Echocardiographic Parameters of Risk Stratification in Pulmonary Arterial Hypertension. Benjamin N, Schiffer V, Resag C, Xanthouli P, Braun M, Harutyunova S, Eichstaedt CA, Egenlauf B, Marra AM, Bossone E, Cittadini A, Kiely DG, Grünig E. J Am Soc Echocardiogr. 2025 Mar;38(3):273-285. doi: 10.1016/j.echo.2024.11.015. Epub 2024 Dec 18. PMID: 39706311.
Mono and combination therapies in pulmonary arterial hypertension patients with comorbidities: A COMPERA analysis. Skowasch D, Pausch C, Huscher D, Pittrow D, Wede J, Kreimendahl F, Rosenkranz S, Beckmann S, Held M, Grünig E, Ghofrani HA, Klose H, Skride A, Halank M, Stadler S, Delcroix M, Vonk-Noordegraaf A, Ewert R, Kopec G, Hoeper MM, Olsson KM. ESC Heart Fail. 2025 Mar 4. doi: 10.1002/ehf2.15254. Epub ahead of print. PMID: 40037846.
Costs of biomarker testing in advanced non-small cell lung cancer: a global study comparing next-generation sequencing and single-gene testing. Malapelle U, Chen CC, de Álava E, Hofman P, Kazdal D, Kim TJ, Lim TKH, Ryška A, Saetta AA, Schuuring E, Troncone G, Biscuola M, Chen YL, Tan GS, Marquette CH, Michelli M, Ter Elst A, Vošmiková H, Kapp J, Gonzalez-McQuire S, Giannopoulou A, Franzini JM, Aramburu VLR, Baggi A, Stenzinger A. J Pathol Clin Res. 2025 Mar;11(2):e70018. doi: 10.1002/2056-4538.70018. PMID: 40052485; PMCID: PMC11886603.
Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators. Botelho HM, Lopes-Pacheco M, Pinto MC, Railean V, Pankonien I, Caleiro MF, Clarke LA, Cachatra V, Neumann B, Tischer C, Moiteiro C, Ousingsawat J, Kunzelmann K, Pepperkok R, Amaral MD. iScience. 2025 Feb 1;28(3):111942. doi: 10.1016/j.isci.2025.111942. PMID: 40040803; PMCID: PMC11876911.
Woche 10 (03.03. - 09.03.)
Pulmonary arteriovenous malformation causing lung sequestration and media infarction: a case report. Griffo R, Klotz LV, Brendel L, Rösch R, Niedermaier B, Schlamp K, Kriegsmann M, Eichhorn MM, Winter H. Front Med (Lausanne). 2025 Feb 11;12:1490820. doi: 10.3389/fmed.2025.1490820. PMID: 40007589; PMCID: PMC11850261.
Die Rolle der Atmungstherapeuten im Weaning von der invasiven Beatmung – Eine Tätigkeitsbeschreibung aus einem zertifizierten Weaning-Zentrum [Role of respiratory therapists in weaning patients from invasive mechanical ventilation: a description of their responsibilities from a certified weaning centre]. Neetz B, Iberl G, Kraus N, Weißmann C, Bornitz F, Müller MM, Reinhardt L, Herth F, Michels J, Trudzinski F. Pneumologie. 2025 Feb 25. German. doi: 10.1055/a-2529-6367. Epub ahead of print. PMID: 39999973.
Woche 9 (24.02. - 02.03.)
Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment. Abooali M, Schlichtner S, Lei X, Aliu N, Ruggiero S, Loges S, Ziegler M, Hertel F, Volckmar AL, Stenzinger A, Christopoulos P, Thomas M, Klenova E, Meyer NH, Boussios S, Heaton N, Zen Y, Zamalloa A, Chokshi S, Urbani L, Richard S, Kirubendran K, Hussain R, Siligardi G, Cholewa D, Berger SM, Yasinska IM, Fasler-Kan E, Sumbayev VV. Cancer Lett. 2025 Feb 19:217581. doi: 10.1016/j.canlet.2025.217581. Epub ahead of print. PMID: 39983894.
Increasing challenges of general practitioner-oncologist interaction in end-of-life communication: a qualitative study. Villalobos M, Korezelidou A, Unsöld L, Deis N, Thomas M, Siegle A. BMC Palliat Care. 2025 Feb 20;24(1):48. doi: 10.1186/s12904-025-01690-w. PMID: 39979926; PMCID: PMC11841224.
Woche 8 (17.02 - 23.02)
Chancen und Barrieren des IPReG für die außerklinische Intensivpflege : Eine explorative Interviewstudie mit Kostenträgern und gesundheitspolitischen Akteuren im Rahmen der „PRiVENT“-Studie [Opportunities and barriers of IPReG for out-of-hospital intensive care : Explorative interview study with payers and health policy stakeholders as part of the PRiVENT study]. Biehler E, Fleischhauer T, Fuchs GE, Forstner J, Weis A, von Schumann S, Michels-Zetsche JD, Trudzinski FC, Herth FJF, Szecsenyi J, Wensing M. Med Klin Intensivmed Notfmed. 2025 Feb 10. German. doi: 10.1007/s00063-025-01247-y. Epub ahead of print. PMID: 39928157.
Neue Indikationen in der Schnittbilddiagnostik der Aorta [New innovations in cross-sectional imaging diagnostics of the aorta]. Melzig C, Böckler D, Kauczor HU, Wielpütz MO, Bischoff MS. Radiologie (Heidelb). 2025 Feb 13. German. doi: 10.1007/s00117-025-01424-2. Epub ahead of print. PMID: 39945846.
Woche 7 (10.02 - 16.02)
Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury. Khadim A, Kiliaris G, Vazquez-Armendariz AI, Procida-Kowalski T, Glaser D, Bartkuhn M, Malik T, Chu X, Moiseenko A, Kuznetsova I, Ahmadvand N, Lingampally A, Hadzic S, Alexopoulos I, Chen Y, Günther A, Behr J, Neumann J, Schiller HB, Li X, Weissmann N, Braun T, Seeger W, Wygrecka M, Morty RE, Herold S, El Agha E. Cell Rep. 2025 Feb 3;44(2):115248. doi: 10.1016/j.celrep.2025.115248. Epub ahead of print. PMID: 39903667.
Outcomes of Pembrolizumab plus chemotherapy for patients with metastatic non-squamous NSCLC: Real-world evidence. Surovtsova I, Herth FJF, Kokh DB, Morakis P. Pulmonology. 2025 Dec 31;31(1):2457856. doi: 10.1080/25310429.2025.2457856. Epub 2025 Feb 5. PMID: 39907049.
Proposal of real-world solutions for the implementation of predictive biomarker testing in patients with operable non-small cell lung cancer. Hofman P, Christopoulos P, D'Haene N, Gosney J, Normanno N, Schuuring E, Tsao MS, Quinn C, Russell J, Keating KE, López-Ríos F. Lung Cancer. 2025 Jan 26;201:108107. doi: 10.1016/j.lungcan.2025.108107. Epub ahead of print. PMID: 39904223.
Woche 6 (03.02 - 09.02)
Risk factors for survival after lung transplantation in cystic fibrosis: impact of colonization with multidrug-resistant strains of Pseudomonas aeruginosa. Weingard B, Becker SL, Schneitler S, Trudzinski FC, Bals R, Wilkens H, Langer F. Infection. 2025 Jan 30. doi: 10.1007/s15010-025-02478-z. Epub ahead of print. PMID: 39883262.
Artificial intelligence for diagnosis and predictive biomarkers in Non-Small cell lung cancer Patients: New promises but also new hurdles for the pathologist. Hofman P, Ourailidis I, Romanovsky E, Ilié M, Budczies J, Stenzinger A. Lung Cancer. 2025 Jan 27;200:108110. doi: 10.1016/j.lungcan.2025.108110. Epub ahead of print. PMID: 39879785.
Efficacy and safety of the activin signalling inhibitor, sotatercept, in a pooled analysis of PULSAR and STELLAR studies. Hoeper MM, Gomberg-Maitland M, Badesch DB, Gibbs JSR, Grünig E, Kopeć G, McLaughlin VV, Meyer G, Olsson KM, Preston IR, Rosenkranz S, Souza R, Waxman AB, Perchenet L, Strait J, Xing A, Manimaran S, Wang X, Miller B, Cornell AG, de Oliveira Pena J, Ghofrani HA, Humbert M. Eur Respir J. 2025 Jan 30:2401424. doi: 10.1183/13993003.01424-2024. Epub ahead of print. PMID: 39884760.
Woche 5 (27.01 - 02.02)
MOMENT registry: Patients with advanced non-small-cell lung cancer harboring MET exon 14 skipping treated with systemic therapy. Thomas M, Christopoulos P, Iams WT, Mazières J, Cortot AB, Peled N, Minuti G, Smit EF, Audhuy F, Berghoff K, Eggleton SP, Fries F, Hildenbrand M, Liu P, Mahmoudpour SH, Menzel C, Oksen D. J Comp Eff Res. 2025 Feb;14(2):e240127. doi: 10.57264/cer-2024-0127. Epub 2025 Jan 21. PMID: 39836056.
Reply to Martin and Grasemann: Is There a Role for Lumacaftor/Ivacaftor in Young Children with Cystic Fibrosis? Stahl M, Röhmel J, Wielpütz MO, Mall MA. Ann Am Thorac Soc. 2025 Jan 21. doi: 10.1513/AnnalsATS.202411-1237LE. Epub ahead of print. PMID: 39836962.
Comparison of the diagnostic performance of non-contrast MR angiography and planar V/Q scintigraphy for pulmonary embolism: a systematic review and meta-analysis. Silva RF, Zanon M, Ackman JB, Forte GC, Altmayer S, Biederer J, Bergmann LL, Andrade RGF, Hochhegger B. Eur Radiol. 2025 Jan 26. doi: 10.1007/s00330-025-11366-x. Epub ahead of print. PMID: 39863727.
Woche 4 (20.01. - 26.01)
Intratumor Heterogeneity Predicts Prognosis in Lepidic Predominant Lung Adenocarcinoma. Niedermaier B, Allgäuer M, Muley T, Schneider MA, Eichhorn ME, Winter H, Klotz LV. Thorac Cancer. 2025 Jan;16(1):e15536. doi: 10.1111/1759-7714.15536. PMID: 39807578; PMCID: PMC11729388.
Woche 3 (13.01. - 19.01)
A reproducibility study on invasion in small pulmonary adenocarcinoma according to the WHO and a modified classification, supported by biomarkers. Thunnissen E, Blaauwgeers H, Filipello F, Lissenberg-Witte B, Minami Y, Noguchi M, Quesne JL, Papotti MG, Flieder DB, Pelosi G, Sansano I, Berezowska S, Ryška A, Brcic L, Motoi N, Nakatani Y, Kuempers C, Hofman P, Hofman V, Dale VG, Rossi G, Ambrosi F, Matsubara D, Ishikawa Y, Weynand B, Calabrese F, Pezzuto F, Kern I, Nicholson S, Mutka A, Dacic S, Beasley MB, Arrigoni G, Timens W, Ooft M, Brinkhuis M, Bulkmans N, Britstra R, Vreuls W, Jones KD, von der Thüsen JH, Hager H, Perner S, Moore D, Leonte DG, Al-Janabi S, Schønau A, Neumann O, Kluck K, Ourailidis I, Ball M, Budczies J, Kazdal D, Stenzinger A. Lung Cancer. 2024 Dec 19;199:108060. doi: 10.1016/j.lungcan.2024.108060. Epub ahead of print. PMID: 39793325.
Automated volumetry of core and peel intrapulmonary vasculature on computed tomography angiography for non-invasive estimation of hemodynamics in patients with pulmonary hypertension (2022 updated hemodynamic definition). Melzig C, Weinheimer O, Egenlauf B, Do TD, Wielpütz MO, Grünig E, Kauczor HU, Heussel CP, Rengier F. Cardiovasc Diagn Ther. 2024 Dec 31;14(6):1083-1095. doi: 10.21037/cdt-24-293. Epub 2024 Dec 19. PMID: 39790187; PMCID: PMC11707475.
Low tumour interleukin-1β expression predicts a limited effect of adjuvant platinum-based chemotherapy for patients with completely resected lung adenocarcinoma: An identification and validation study. Authors´reply. Safi S, Benner A, Beckhove P, Muley T. Pulmonology. 2025 Dec 31;31(1):2447637. doi: 10.1080/25310429.2024.2447637. Epub 2025 Jan 8. PMID: 39773309.
Outcome and safety 90 days after combined airway valve treatment of the right upper and middle lobes in patients with severe pulmonary emphysema. Dittrich AS, De Pace CC, Brock JM, Trudzinski F, Heussel CP, Eberhardt R, Herth FJF, Kontogianni K. Respir Res. 2025 Jan 6;26(1):4. doi: 10.1186/s12931-024-03069-6. PMID: 39762833; PMCID: PMC11706069.
Woche 2 (06.01. - 12.01.)
Malignancy risk stratification for pulmonary nodules: comparing a deep learning approach to multiparametric statistical models in different disease groups. Piskorski L, Debic M, von Stackelberg O, Schlamp K, Welzel L, Weinheimer O, Peters AA, Wielpütz MO, Frauenfelder T, Kauczor HU, Heußel CP, Kroschke J. Eur Radiol. 2025 Jan 2. doi: 10.1007/s00330-024-11256-8. Epub ahead of print. PMID: 39747589.
Woche 1 (30.12.24 - 05.01.25)
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